Microfilament-associated Triple Complex: Structure, Function and Drug Targets

Target Name: Microfilament-associated triple complex

NCBI ID: P18289

Other Name(s): Microfilament-associated myosin Vb.Rab11a.Rab11-FIP2 triple complex

Microfilament-associated Triple Complex: Structure, Function and Drug Targets

Microfilament-associated triple complex is a protein structure that is found in the cytoskeleton of eukaryotic cells. It is a complex of three proteins: Myosin Vb.Rab11, Myosin Vb.Rab11-FIP2, and Myosin Vb.Rab11-ALC. These proteins work together to regulate the movement of cells in various ways, including the contraction and relaxation of muscle cells and the movement of vesicles within cells.

The Microfilament-associated triple complex is a critical structure in the cytoskeleton because it helps to maintain the integrity and structure of the cytoskeleton. It is made up of three subunits: Myosin Vb.Rab11, Myosin Vb.Rab11-FIP2, and Myosin Vb.Rab11-ALC. These proteins are held together by a series of interactions between their amino acid residues, including a disulfide bond.

Myosin Vb.Rab11 is the protein that is responsible for the power generation of the microfilaments. It is a type of myosin protein that is characterized by its ability to generate force in a direction that is perpendicular to the force field. Myosin Vb.Rab11 is also known for its role in the regulation of cell division and the development of cancer.

Myosin Vb.Rab11-FIP2 is a protein that is involved in the regulation of the microfilament stability. It helps to keep the microfilaments in a stable state, which is essential for the proper functioning of the cytoskeleton.

Myosin Vb.Rab11-ALC is a protein that is involved in the regulation of the cytoskeleton. It helps to regulate the amount of microfilaments that are present in the cytoskeleton, which is important for the proper functioning of the cell.

The Microfilament-associated triple complex plays a crucial role in the regulation of cellular processes in eukaryotic cells. It is involved in the regulation of cell division, the development of cancer, and the regulation of the cytoskeleton. As a result, it is an attractive drug target for researchers who are seeking to understand the mechanisms of these processes and to identify new treatments for a variety of diseases.

Protein Name: Microfilament-associated Triple Complex

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